OC-088 CAN PROCOLLAGEN I AND PROCOLLAGEN III SERVE AS PREDICTIVE BIOMARKERS FOR INCISIONAL HERNIA RECURRENCE?

Abstract Background The aim of this study was to determine the temporal evolution extracellular matrix (ECM) remodelling and collagen biomarkers their influence on incisional hernia recurrence after IPOM plus repair. Methods A sub-cohort patients (n=25) undergoing laparoscopic repair within TACKoMesh randomised controlled trial were bled at serial timepoints up 1-year following surgery. Serum/plasma concentration (Procollagen I, Procollagen III, Fibronectin, TGF-beta, MMP-2, MMP-9, TIMP-1, TIMP-2) quantified using ELISA Luminex multiplex techniques. Data described compared between groups that developed remained free from R statistical software. Results I reduced relative baseline post-op Day 1 but increased Days 6 30 (p<0.05). III showed an elevation 30. Lower levels detected 0, (p<0.05) higher 1, in with a recurrence. Fibronectin whilst TGF-β MMP-2 its inhibitor TIMP-2 post-operative MMP-9 persistently than all timepoints. TIMP-1 elevated No differences found circulating concentrations these predict Conclusion In recurrence, low high detected.